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Journal of Obstrectics and Gynaecological Research, Kaplan, S. Kessler, T. Koda-Kimble, et al. Applied therapeutics: the clinical use of drugs, 7th ed. Kosilov, K.

Archives of Gerontology and Geriatrics, Khullar, V. Kuo, H-C. Neurology and Urodynamics, Lee, J.

International Journal of Urology, Leung, H. A randomized controlled trial of tolterodine and oxybutynin on tolerability and clinical efficacy for treating Chinese women with an overactive bladder. Madersbacher, H. Trospium chloride vs. Malone-Lee, J. The comparative tolerability and efficacy of tolterodine 2 mg bid vs. Tolterodine: superior tolerability than and comparable efficacy to oxybutynin in individuals 50 years old or older with overactive bladder: a randomized controlled trial.

Maman, K. McEvoy, et al. Milani, R. Double-blind crossover comparison of flavoxate and oxybutynin in women affected by urinary-urge syndrome. Int Urogynecol J, Nilsson, C. Comparison of a mg controlled release oxybutynin tablet with a 5-mg oxybutynin tablet in urge incontinent patients. Radomski, S. Preliminary evaluation of a new controlled release oxybutynin in urinary incontinence. Current Medical Research and Opinion, Sand, P. A comparison of extended-release oxybutynin and tolterodine for treatment of overactive bladder in women.

Urinary incontinence update: Bold traditions and new concepts. Adv Intern Med. Sussman, D. Swift, S. A new once-daily formulation of tolterodine provides superior efficacy and is well tolerated in women with overactive bladder. Van Kerrebroeck, P.

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Tolterodine once-daily: superior efficacy and tolerability in the treatment of the overactive bladder. Serment, and E.

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Clinical efficacy and safety of tolterodine compared to oxybutynin in patients with overactive bladder [abstract]. Versi, E. Dry mouth with conventional and controlledrelease oxybutynin in urinary incontinence. Yamaguchi, O. BJU International. Zeegers, A. Conservative therapy of frequency, urgency, and urge incontinence: A double-blind clinical trial of flavoxate hydrochloride, oxybutinin chloride, emepronium bromide, and placebo. Zellner, M. Zinner, N. Tuttle, and L. Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist M3 SRA , compared with oxybutynin in the treatment of patients with overactive bladder.

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Forgot password? Check this box if you wish to have a copy mailed to you. Overactive Bladder is Not Normal. You might not need a drug. Nondrug treatments can be very helpful, and are usually—and should be—recommended before drugs for most people. Nondrug Treatments Most people with overactive bladder can get the relief they need with lifestyle changes, such as cutting back on caffeinated beverages and drinking less fluid between dinner and bedtime, doing Kegel exercises , and bladder training. Should You Try Botox injections? Comparing Drug Safety and Effectiveness The overactive bladder drugs are only moderately effective.

Additional Precautions Since older people are more likely to have overactive bladder, doctors are especially alert to any mental confusion they might experience. Table 1. Using Medication. How We Made Our Recommendation. References Abrams P. Detrol LA package insert. Ditropan XL package insert. Myrbetriq package insert. Couture JA, Valiquette L.

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Urinary incontinence. Ann Pharmacother. Editor's Note: These materials are made possible by a grant from the state Attorney General Consumer and Prescriber Education Grant Program, which is funded by the multi-state settlement of consumer-fraud claims regarding the marketing of the prescription drug Neurontin gabapentin.